RIRAAF

Proyectos de Investigación en curso (año 2008 y siguientes).

 

PI051056. FIS Instituto de Salud Carlos III.

Investigador Principal: José Augusto García-Agúndez Pérez-Coca


PI061252. FIS Instituto de Salud Carlos III.

Investigadora Principal: Elena García-Martín


PRI07A006. Junta de Extremadura

Investigador Principal: José Augusto García-Agúndez Pérez-Coca


RD07/0064/0016. FIS estructuras estables de investigación cooperativa RETICS.

Investigador Principal: José Augusto García-Agúndez Pérez-Coca



Publicaciones recientes (año 2008).



Agúndez J.A., Golka K., Martínez C., Selinski S., Blaszkewicz M., García-Martín E.

Unraveling Ambiguous NAT2 Genotyping Data

Clinical Chemistry 2008, 54(8), in press.


M. Isabel Lucena, Raúl J. Andrade, Carmen Martínez, Eugenia Ulzurrun, Elena García-Martín, Yolanda Borraz, M. Carmen Fernández, Manuel Romero-Gomez, Agustin Castiella, Ramón Planas, Joan Costa, Sandra Anzola, José A.G. Agúndez, on behalf of GEHAM.

Glutathione-S-transferase M1 and T1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury.

Hepatology 2008, in press. DOI: 10.1002/hep.22370


Agúndez JA.

Polymorphisms of Human N-Acetyltransferases and Cancer Risk

Current Drug Metabolism 2008 July;9(6):520-31.


Agúndez JA.

N-Acetyltransferases: Lessons Learned from Eighty Years of Research

Current Drug Metabolism 2008 July;9(6):463-4.


Ledesma MC, García-Martín E, Alonso-Navarro H, Martínez C, Jiménez-Jiménez FJ, Benito-León J, Puertas I, Rubio L, López-Alburquerque T, Agúndez JA.

The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is Associated to the Risk of Developing Essential Tremor.

Neuromolecular Med. 2008 Jun 10. [Epub ahead of print]


Tomlinson IP, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman AM, Spain S, Lubbe S, Walther A, Sullivan K, Jaeger E, Fielding S, Rowan A, Vijayakrishnan J, Domingo E, Chandler I, Kemp Z, Qureshi M, Farrington SM, Tenesa A, Prendergast JG, Barnetson RA, Penegar S, Barclay E, Wood W, Martin L, Gorman M, Thomas H, Peto J, Bishop DT, Gray R, Maher ER, Lucassen A, Kerr D, Evans DG; CORGI Consortium, Schafmayer C, Buch S, Völzke H, Hampe J, Schreiber S, John U, Koessler T, Pharoah P, van Wezel T, Morreau H, Wijnen JT, Hopper JL, Southey MC, Giles GG, Severi G, Castellví-Bel S, Ruiz-Ponte C, Carracedo A, Castells A; EPICOLON Consortium, Försti A, Hemminki K, Vodicka P, Naccarati A, Lipton L, Ho JW, Cheng KK, Sham PC, Luk J, Agúndez JA, Ladero JM, de la Hoya M, Caldés T, Niittymäki I, Tuupanen S, Karhu A, Aaltonen L, Cazier JB, Campbell H, Dunlop MG, Houlston RS.

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Nat Genet. 2008 May;40(5):623-30. Epub 2008 Mar 30.


García-Martín E, Ayuso P, Luengo A, Martínez C, Agúndez JA.

Genetic variability of histamine receptors in patients with Parkinson's disease.

BMC Med Genet. 2008 Mar 17;9:15.


Agúndez JA, Ladero JM.

Glutathione S-transferase GSTT1 and GSTM1 allozymes: beyond null alleles.

Pharmacogenomics. 2008 Mar;9(3):359-63.


García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ.

Histamine-N-Methyl Transferase Polymorphism and Risk for Migraine.

Headache. 2008 Feb 4. [Epub ahead of print]


Blanco G, Martínez C, Ladero JM, Garcia-Martin E, Taxonera C, Gamito FG, Diaz-Rubio M, Agundez JA.

Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding.

Pharmacogenet Genomics. 2008 Jan;18(1):37-43.


Martínez C, García-Martín E, Alonso-Navarro H, Benito-León J, Puertas I, Rubio L, López-Alburquerque T, Agúndez JA, Jiménez-Jiménez FJ.

Glutathione-S-transferase P1 polymorphism and risk for essential tremor.

Eur J Neurol. 2008 Mar;15(3):234-8. Epub 2008 Jan 22.


Agúndez JA, Luengo A, Herráez O, Martínez C, Alonso-Navarro H, Jiménez-Jiménez FJ, García-Martín E.

Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease.

Neuromolecular Med. 2008;10(1):10-6.